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Antioxidant, Anti-Inflammatory, and Anticancer Activities of Ethanolic Chayote (Sechium edule) Fruit Extract: Phytochemical Insights and Therapeutic Implications | ||
| Agrotechniques in Industrial Crops | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 13 آذر 1404 اصل مقاله (469.68 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22126/atic.2026.12170.1221 | ||
| نویسندگان | ||
| Somayeh Rahaiee* 1؛ Saeed Ghanbari Hassan Kiadeh1؛ Mostafa Govahi2؛ Mostafa Ghasemi1 | ||
| 1Department of Microbial Biotechnology, Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran | ||
| 2Department of Nano Biotechnology, Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran | ||
| چکیده | ||
| Chayote (Sechium edule) is a valuable species of the Cucurbitaceae family, widely consumed in many countries due to its diverse nutritional and bio-functional properties. This study was designed to evaluate the phenolic compounds (using Folin-Ciocalteu and aluminum chloride methods), antioxidant (via DPPH assay), anti-inflammatory, and anti-cancer activity (by MTT assay) of chayote fruit ethanolic extract (CFE). The results showed that the CFE contains high phenolic and flavonoid compounds with concentration-dependent and appropriate antioxidant activity. Approximately 62 ± 0.53 % of DPPH free radicals were inhibited at the 200 μg mL-1 concentration (IC50 = 35.40 μg mL-1). Also, the results of the anti-inflammatory activity indicated that CFE significantly prevents protein denaturation. The highest inhibitory effect at 800 μg mL-1 was 63.37 ± 2.14 %. Further, the CFE anticancer activity results on breast cancer cell lines (MCF-7) indicated its significant toxicity (IC50 = 42.04 μg mL-1) after 24 h. However, no significant toxicity was observed in normal mouse fibroblast cells (L929). Generally, this study demonstrates that CFE is rich in bioactive compounds with antioxidant, anti-inflammatory, and anticancer effects, making it a promising candidate for use in functional foods and pharmaceutical applications. | ||
تازه های تحقیق | ||
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| کلیدواژهها | ||
| Anticancer activity؛ Anti-inflammatory؛ Bioactive compounds؛ Functional foods؛ Natural antioxidants | ||
| مراجع | ||
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