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A novel biosensor based on horseradish peroxidase trapped in silica Sol-Gel/MWCNTs matrix for methyldopa determination in medical and pharmaceutical samples | ||
| Advances in Nanochemistry | ||
| مقاله 2، دوره 1، شماره 1، فروردین 2019، صفحه 6-11 اصل مقاله (1.65 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22126/anc.2019.3242.1003 | ||
| نویسندگان | ||
| Javad Ghodsi؛ Amir Abbas Rafati* ؛ Yalda Shoja | ||
| Department of Physical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, P.O.Box 65174, Hamedan, Iran | ||
| چکیده | ||
| A modified electrode composed of horseradish peroxidase (HRP) trapped onto silica Sol-Gel/multi-walled carbon nanotubes (MWCNTs) matrix on carbon paste electrode (CPE) developed and applied for determination of methyldopa by electrocatalytic oxidation of methyldopa with HRP for the first time. The proposed biosensor showed linear response in two ranges of 1 μmol L-1 to 3.5 mmol L-1 and 3.5 mmol L-1 to 12 mmol L-1, and detection limit was obtained about 25.3 nmol L-1. The biosensor performance was much better than a lot of previously reported sensors and biosensors for methyldopa determination. This modified electrode was successfully used for accurate determination of methyldopa in urine and pharmaceutical samples. Using the developed biosensor provided an accurate, sensitive and repeatable method for methyldopa measurement in pharmaceutical and urine samples. | ||
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